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KMID : 0191120200350300280
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Journal of Korean Medical Science
2020 Volume.35 No. 30 p.280 ~ p.280
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Clinical Course and Outcomes of 3,060 Patients with Coronavirus Disease 2019 in Korea, January?May 2020
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Sung Ho-Kyung
Kim Jin-Yong
Heo Jeong-Hun
Seo Hae-Sook
Jang Young-Soo
Kim Hye-Won
Koh Bo-Ram
Jo Neung-Sun
Oh Hong-Sang
Baek Young-Mi
Park Kyung-Hwa
Shon Jeung-A
Kim Min-Chul
Kim Joon-Ho
Chang Hyun-Ha
Park Yu-Kyung
Kang Yu-Min
Lee Dong-Hyun
Oh Dong-Hyun
Park Hyun-Jung
Song Kyoung-Ho
Lee Eun-Kyoung
Jeong Hyeong-Seok
Lee Ji-Yeon
Ko Ja-Young
Choi Ji-Hee
Ryu Eun-Hwa
Chung Ki-Hyun
Oh Myoung-Don
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Abstract
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Background: The fatality rate of patients with coronavirus disease 2019 (COVID-19) varies among countries owing to demographics, patient comorbidities, surge capacity of healthcare systems, and the quality of medical care. We assessed the clinical outcomes of patients with COVID-19 during the first wave of the epidemic in Korea.
Methods: Using a modified World Health Organization clinical record form, we obtained clinical data for 3,060 patients with COVID-19 treated at 55 hospitals in Korea. Disease severity scores were defined as: 1) no limitation of daily activities; 2) limitation of daily activities but no need for supplemental oxygen; 3) supplemental oxygen via nasal cannula; 4) supplemental oxygen via facial mask; 5) non-invasive mechanical ventilation; 6) invasive mechanical ventilation; 7) multi-organ failure or extracorporeal membrane oxygenation therapy; and 8) death. Recovery was defined as a severity score of 1 or 2, or discharge and release from isolation.
Results: The median age of the patients was 43 years of age; 43.6% were male. The median time from illness onset to admission was 5 days. Of the patients with a disease severity score of 3?4 on admission, 65 (71.5%) of the 91 patients recovered, and 7 (7.7%) died due to illness by day 28. Of the patients with disease severity scores of 5?7, 7 (19.5%) of the 36 patients recovered, and 8 (22.2%) died due to illness by day 28. None of the 1,324 patients who were < 50 years of age died; in contrast, the fatality rate due to illness by day 28 was 0.5% (2/375), 0.9% (2/215), 5.8% (6/104), and 14.0% (7/50) for the patients aged 50?59, 60?69, 70?79, and ≥ 80 years of age, respectively.
Conclusion: In Korea, almost all patients of < 50 years of age with COVID-19 recovered without supplemental oxygen. In patients of ≥ 50 years of age, the fatality rate increased with age, reaching 14% in patients of ≥ 80 years of age.
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KEYWORD
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COVID-19, SARS-CoV-2, Prognosis, Cohort Study, Korea
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